产品货号：
Z37116
中文名称：
KU80/XRCC5抗体
英文名称：
Anti-KU80/XRCC5 Antibody (Clone#5C5)
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-KU80/XRCC5 Antibody (Clone#5C5) |
| 指标别名 | 86kDa subunit of Ku antigen;CTC85;CTCBF;DNA repair protein XRCC5;G22P2;KARP 1;KARP1;Ku80;Ku86;KUB2;NFIV;Nuclear factor IV;Thyroid lupus autoantigen;TLAA;XRCC5;XRCC5/Ku80 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,IHC,IF,FCM,ELISA |
| 基因名称 | XRCC5 |
| 克隆号 | 5C5 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG |
| 免疫原 | Purified recombinant fragment of human Ku-80 expressed in E.Coli. |
| 计算分子量 | 83KD |
| 成分 | Ascitic fluid containing 0.03% sodium azide. |
| 纯化方式 | Affinity purification |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | XRCC5 (X-ray Repair,Complementing Defective,In Chinese Hamster,5),also known as Ku80 or Ku86,is a protein that in humans,is encoded by the XRCC5 gene.The XRCC5 gene encodes the 80-kD subunit of the Ku autoantigen,a heterodimer which contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous end joining (NHEJ) pathway.The XRCC5 gene is mapped to 2q35.Human colon cancer cells heterozygous for Ku86 are haploinsufficient with an increase in polyploid cells,a reduction in cell proliferation,elevated p53 levels,and a slight hypersensitivity to ionizing radiation.Functional inactivation of the second Ku86 allele results in cells with a drastically reduced doubling time.The Ku86 locus is essential in human somatic tissue culture cells by experiments demonstration.A rare microsatellite polymorphism in XRCC5 is associated with cancer in patients of varying radiosensitivity. |
| Uniprot ID | P13010 |
| 基因名全称 | X-ray repair cross-complementing protein 5 |
| 蛋白名全称 | X-ray repair cross-complementing protein 5 |
| 推荐稀释比 | WB 1:500～1:2000 IHC 1:200～1:1000 IF 1:200～1:1000 FC 1:200～1:400 ELISA 1:10000 |
相关搜索：KU80/XRCC5抗体，KU80抗体，XRCC5单抗，Anti-KU80/XRCC5 Antibody (Clone#5C5)